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  • 참여교원

연구인력

참여교원

  • 부교수
  • 조한상
    Lab 인간생체모사칩 연구실
CV1

관심분야

미세유체역학 기반의 뇌 칩 및 장기 칩; 
표면플라즈모닉 기반의 광유체 기구; 
생체 진단 및 환경 감시용 센서

학력

  • 박사: 캘리포니아 버클리 주립대학 의용공학과;
  • 석사: 서울대 기계설계학과;
  • 학사: 서울대 기계설계학과

약력/경력

  • 2014.08 – 현재: 조교수, Mechanical Engineering and Engineering Science, University of North Carolina at Charlotte;
  • 2010.09 – 2014.08: 포스닥, Harvard Medical School, Massachusetts General Hospital, and Shriners Hospital;
  • 2003.01 – 2005.08: 연구원, 한국과학기술연구원;
  • 1999.03 – 2003.01: 연구원/팀장, 바이오메드랩;
  • 1998.05 – 1999.03: 연구원, 현대자동차

학술지 논문

  • (2024)  Microglia gravitate toward amyloid plaques surrounded by externalized phosphatidylserine via TREM2.  ADVANCED SCIENCE.  11,  34
  • (2024)  Neurotoxic Microglial Activation via IFN𝜸-Induced Nrf2 Reduction Exacerbating Alzheimer’s Disease.  ADVANCED SCIENCE.  12,  1
  • (2024)  Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflammatory Responses.  ADVANCED SCIENCE.  11,  1
  • (2023)  Laminin-Augmented Decellularized Extracellular Matrix Ameliorating Neural Differentiation and Neuroinflammation in Human Mini-Brains.  SMALL.  19,  1
  • (2023)  Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration.  NATURE PROTOCOLS.  18,  9
  • (2023)  Astrocytic scar restricting glioblastoma via glutamate-MAO-B activity in glioblastoma-microglia assembloid.  BIOMATERIALS RESEARCH.  27,  1
  • (2022)  Human mini-blood-brain barrier models for biomedical neuroscience research: a review.  BIOMATERIALS RESEARCH.  26,  1
  • (2022)  Nanomedicine for advanced cancer immunotherapy.  JOURNAL OF CONTROLLED RELEASE.  351,  -
  • (2022)  Neuroinflammation in neurodegeneration via microbial infections.  FRONTIERS IN IMMUNOLOGY.  13,  -
  • (2022)  Adipokine human Resistin promotes obesity-associated inflammatory intervertebral disc degeneration via pro-inflammatory cytokine cascade activation.  SCIENTIFIC REPORTS.  12,  1
  • (2022)  TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.  ELIFE.  11,  -
  • (2021)  An Air Particulate Pollutant Induces Neuroinflammation and Neurodegeneration in Human Brain Models.  ADVANCED SCIENCE.  8,  21
  • (2021)  Oral Pathogenic Bacteria-Inducing Neurodegenerative Microgliosis in Human Neural Cell Platform.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  22,  13
  • (2021)  Human brain organoids in Alzheimer’s disease.  Organoid.  1,  1
  • (2021)  Time-Dependent Internalization of Polymer-Coated Silica Nanoparticles in Brain Endothelial Cells and Morphological and Functional Effects on the Blood-Brain Barrier.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  22,  4
  • (2021)  Human mini-brain models.  NATURE BIOMEDICAL ENGINEERING.  5,  1
  • (2020)  Therapeutic Targeting Strategies for Early- to Late-Staged Alzheimer's Disease.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  21,  24
  • (2020)  Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2- production.  NATURE NEUROSCIENCE.  23,  12
  • (2020)  Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.  NATURE COMMUNICATIONS.  11,  1
  • (2019)  Electrical impulse effects on degenerative human annulus fibrosus model to reduce disc pain using micro-electrical impulse-on-a-chip.  SCIENTIFIC REPORTS.  9, 

수상/공훈

  • Junior Faculty Award by Association of Korean Neuroscientists (2018); Cure Alzheimer’s Fund awards (2015, 2016, 2017, 2018); NIH award (2019); Lawrence scholar program fellowship (2007); Fellowship supported by Intel Inc. (2006); Scholarship supported by the Korea research foundation grant funded by the Korea government (2005); Graduation with cum laude from Seoul National University (1996)

학술회의논문

  • (2022)  Fine particulate matter in air pollutants promotes neuroinflammation and exacerbates tauopathy in human minibrain.  2022 Int'l Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders.  스페인
  • (2022)  Air particulate pollutant inducing neurodegenerative inflammation,” 3rd International Webinar on Dementia and Alzheimer Rehabilitation.  3rd International Webinar on Dementia and Alzheimer Rehabilitation.  영국
  • (2022)  Human 3D Mini-Brain Model for the Study of Neurological Disorders.  2022년 한국뇌신경과학회 신경교세포분과 정기학술대회.  대한민국
  • (2021)  Oral Pathogenic Bacteria-Inducing Neurodegenerative Microgliosis in Human Neural Cell Platform.  5th International Webinar on Global Advanced Nursing, Patient Safety and Healthcare.  영국
  • (2021)  Glial Scar Causing Drug Resistance and Inhibiting Glioblastoma Growth in a 3D Human Glioblastoma Microenvironment.  the Society for Neuroscience’s annual meeting 2021.  미국
  • (2021)  Organoid Standardization, Clinical Application and Regeneration.  International Conference of the Organoid Society 2021.  대한민국
  • (2021)  Construction of 3D Glial Scared-GBM Microenvironment and increase of Drug Sensitivity by KDS20210.  INTERNATIONAL SYMPOSIUMON REACTIVE ASTROCYTES AND GLIOBLASTOMA.  대한민국
  • (2021)  From disease research to successful commercialization based on organoids.  Organoid Bench to Business Symposium 2021.  대한민국
  • (2021)  Construction of in vitro Human Brain Models.  오가노이드 미니심포지엄 2021.  대한민국
  • (2020)  Assessment of neurodegenerative microgliosis induced by oral pathogenic bacteria.  Neurodegenerative Diseases: Biology & Therapeutics.  미국
  • (2020)  3D Human Brain models in Microfluidics for the Study of Neurological Disorders.  제1회 바이오융합세미나.  대한민국
  • (2019)  3D human brain model in Alzheimer’s disease.  2019 한국바이오칩학회 추계학술대회.  대한민국
  • (2019)  Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via excessive H2O2-production.  the 10th World Congress of Neuroscience.  대한민국