[행사/세미나] IPHC Seminar Series / 4. 27.
- 지능형정밀헬스케어융합학과
- 조회수839
- 2021-04-15
Quantitative Brain MRI Imaging
(Prof. Roh-Eul Yoo, MD, Seoul National University Hospital)
Various quantitative brain MR imaging has facilitated the early diagnosis and prognostication of CNS diseases and enabled us to understand the pathophysiology underlying the diseases. Of those, arterial spin labeling (ASL) and dynamic contrast-enhanced (DCE) perfusion-weighted MR imaging (PWI) can provide quantitative perfusion parameters. In ASL-PWI, magnetically labeled water molecules reduce the longitudinal magnetization vector, which in turn leads to the reduced image signal. Subsequently, subtraction of the labelled image from the control image provides CBF map on ASL-PWI. Dynamic contrast-enhanced (DCE) MR imaging is based on T1 shortening induced by a gadolinium-based contrast bolus passing through tissue. Various quantitative model-based and semiquantitative model-free pharmacokinetic parameters, that reflect microcirculatory structure and function, can be derived using the technique. More recently, quantitative T1 mapping has been used to delineate the CSF circulation via the glymphatic system, an emerging circulatory model in the brain known to be involved in the glial-dependent waste clearance pathway. This lecture will focus on the use of the aforementioned quantitative imaging techniques in neuroimaging in the routine clinical and research settings.